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IJERT-EMS

Synthesis and Characterization of 4-Amino Antipyrine Based Schiff Base Complexes: Antimicrobial, Cytotoxicity and DNA Cleavage Studies


Synthesis and Characterization of 4-Amino Antipyrine Based Schiff Base Complexes: Antimicrobial, Cytotoxicity and DNA Cleavage Studies
Authors : R. Jayalakshmi , D. Dhivya Priya , V. Jayakkumar, Dr. R. Rajavel
Publication Date: 31-07-2017

Authors

Author(s):  R. Jayalakshmi , D. Dhivya Priya , V. Jayakkumar, Dr. R. Rajavel

Published in:   International Journal of Engineering Research & Technology

License:  This work is licensed under a Creative Commons Attribution 4.0 International License.

Website: www.ijert.org

Volume/Issue:   Volume. 6 - Issue. 08 , August - 2017

e-ISSN:   2278-0181

 DOI:  http://dx.doi.org/10.17577/IJERTV6IS080005

Abstract

A series of novel Cu(II), Co(II), Ni(II) and Mn(II) complexes were synthesized from the Schiff base obtained by the condensation of 4-aminoantipyrine with furfuraldehyde and dl-cysteine. Their structural features and other properties were explored from the analytical and spectral methods. The measured low molar conductance values in DMF indicate that the complexes are non-electrolytes. The stoichiometry of the obtained complexes and the bonding modes of the ligand were found to depend on both nature of metal and ligand. The grain size of the complexes was calculated by Scherer’s formula using powder XRD. The bio-efficacy of the ligand and their complexes has been examined against the growth of bacteria and fungi in vitro to evaluate their anti-microbial potential. The Schiff base and their metal complexes were evaluated using neuroblastoma SH-SY5Y cell lines. DNA-cleavage studies with CT-DNA have shown that more obvious activity against both Schiff base and its metal complexes in the presence of H2O2.

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