A Review on the Abnormalities of Diabetic Retinal Images

DOI : 10.17577/IJERTV3IS040177

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A Review on the Abnormalities of Diabetic Retinal Images

E . Dhiravidachelvi

Research scholor,

Electronics and communication Engineering Sathyabama University

Chennai,Tamilnadu

Dr. V. Rajamani

professor

Electronics and Communication Engineering veltech-multi tech engineering college chennai, Tamil nadu.

Abstract: In recent biomedical field, ophthalmology has a significant role. In order to identify and detect the pathologies in diabetic retinopathy accurately, and correctly converge on time, it requires computer aided techniques. This paper focuses the various abnormalities of the retinal images and its procedure of the automated techniques involved in it. And also it provides performance analysis in terms of sensitivity and specificity calculations for the various techniques behind the micro aneurysms, exudates and hemorrhages.

Keywords: Diabetic retinopathy, abnormalities, micro aneurysms, exudates, hemorrhages

1. INTRODUCTION Diabetic Retinopathy (damage to retina)

The main cause of vision loss is the diabetic retinopathy and

its prevalence is set to continue rising. The early detection may be used to encourage improvement in diabetic control. When the small blood vessel in the retina has a high level of glucose, the vision will be blurred. Over a period of time the retina has some abnormalities like microanesysms, exudates and hemorrhages. For the diagnosis, ophthalmologists use color retinal images of a patient acquired from digital fundus camera. Prolonged diabetes causes micro vascular leakage and micro vascular blockage within the retinal blood vessels.

Fig1: retinal image

The literature on the automatic retinal image diagnosing algorithms are classified to the following steps

  1. Preprocessing

  2. Feature Extraction/segmentation

  3. Classification

    2. LITERATURE

    1. EXUDATES:

One of the visible signs. These are extends into the macula area, vision loss can occur. The exudates can be classified as Hard, Soft Exudates; hard exudates (intra retinal lipid exudates) are yellow deposits of lipid and protein within the sensory retina. Soft exudates (cotton wool spots) they are white, fluffy lesions in the nerve fiber layer.

Fig2: Soft Exudates Hard Exudates

analysis.

6

Fine

Akara

Resizing

Morphologic

Morphology:

Exudates

Sophara

/RGB to

al

Sensitivity

Detection

k,

HIS/CL

Reconstructi

88.1%

using

Bunyarit

AHE

on

Specificity

morphologi

Uyyanon

99.2%

cal

vara.

Accuracy

Reconstruct

99%,

ion

Fem:

Enhanceme

Sensitivity

nt

97.2%

Specificity

85.4%

Accuracy

85.6%

7

Exudates

Ivo

Green

Morphologic

Sensitivity

Dynamic

Soares,

channel

al operators

97.49%

Detection

Miguel

and adaptive

Specificity

in Retinal

castelo

thresholding

99.95%

Fundus

Branco

Accuracy

images

99.91%

based on

the Noise

map

distribution

8

Automatic

G.Ferdic

Genetic

Baseline

Not

optic Disc

Mashak

Algorith

method

mentioned

Detection

Ponnaia

m

and

h,

Removal of

Capt.Dr.

false

S.Santho

Exudates

sh

for

Baboo

Improving

Retinopath

y

classificatio

n Accuracy

9

An

Nan

Green

Boosted soft

Sensitivity

Effective

Yang,

channel/

Segmentatio

99.64%

Frame

Hu

CLAHE

n/Backgroun

Specificity

work for

Chaun

d Subtraction

87.86%

Automatic

Lu

Accuracy

Segmentati

93.78%

on of Hard

Exudates in

Fundus

Images

10

Detection

Diptonee

Grayscal

Simulated

Sensitivity

of Hard

l Kayal

e/Media

Anealing/Thr

98.66%

Exudates

and

n

esholding

Predictivity

using

Sreeparn

filter/Im

98.12%

Simulated

a

age

Annealing

Banerjee

Subtratio

based

n

Thresholdin

g

Mechanism

in digital

retinal

fundus

image

11

Computeriz

Sidra

CLAHE

Fuzzy

Not

ed

Rashid

Clusterin

clustering

mentioned

Exudates

g

(FCM)

Detection

in Fundus

Images

using

statistical

TABLE 1

s. no

Title

Author

Preproc essing

Method

Result

1

Automatic udates tection from abetic tinopathy tinal image

ing Fuzzy. C- eans and orphological ethods.

Akara Sophara k, Bunyarit Uyyanon vara.

RGB to HSI

Media filtering CLAHE

FCM

clustering: 2.Coarse segmentation FCM

3.Fine segmentation Morphologic al

reconstructio n

Time taken for running 6 minutes Sensitivity 86%

Specificity 99%

2

Hybrid Approach for Detection of Hard Exudates

Dr. H.B.

Kekre, Dr.

Tanuja, K.

Sarode, Ms.

Tarannu m Parker

Resizing

/ Green Channel

Clustering: Linde-Buzo- Gray Algorithms

Morphology based approach: sensitivity 91%

specificity 39%

accuracy 67%, LGB:

sensitivity 80%

specificity 57%

accuracy 68%,

K means: sensitivity 77%

specificity 76%

accuracy 76%,

3

Detection of Exudates for the

diagnosis of diabetic Retinopath

y

Anitha Somasun daram, and Janardha na

Prabhu

RGB –

HSV/Me dium filtering/ Enhance ment

Score computation technique

Not mentioned

4

Localizatio n of Hard Exudates in Retinal Fundus Image by Mathematic al

Morpholog y operation.

Mehdi Ghafouri an Fakhar, Hamidre za Pourreza

Green channel

morphologic al/Top operation

Sensitivity 78.28%

5

Detection of Exudates on Diabetic Retinopath y images based on morphologi cal operation and connected

component

M.

Ponnibal a, S.

Mohana Priya

Green channel,/ HE

Morphologic al connected component

Not mentioned

feature based Fuzzy c-

mean clustering

12

Comparativ

Alireza

Green

SVM/NN

SVM:

e Exudates

Osareh,

channel

Sensitivity

classificatio

Majid

83.3%

n using

Mirmeh

Specificity

Support

di

95.5%

vector

machines

and Neural

networks

13

A Segment

Atul

Resizing

Morphologic

Sensitivity

based

Kumar,

/Color

al/Matched

97.1%

Technique

Manish

normaliz

filter/SVM

Specificity

for

Srivasta

ation

98.3%

detecting

va, A.K.

green

Exudates

Sinha

channel/

from

noise

Retinal

removal/

fundus

AHE

image

14

Neural

Maria

Green

Neural

MLP:

Network

Garcia,

channel

network

Sensitivity

based

Clara I.

contrast

MLP

100%

detection of

Sanchez

enhance

RBF

Specificity

hard

ment

SVM

92.59%

exudates in

RBF:

retinal

Sensitivity

images

100%

Specificity

81.48%

SVM:

Sensitivity

100%

Specificity

77.78%

15

Automatic

Kittipol

HIS/cont

Binary

Sensitivity

detection of

Wisaing,

rast

segmentation

96.7%

Exudates in

Nualswa

enhance

FCM

Specificity

diabetic

t

ment

clustering

71.4%

Retinopath

Accuracy

y Images

79%

16

Automated

Hussain

green

Split and

Sensitivity

Detection

F.Jaafer,

channel

merge

89.3%

of Exudates

Asoke

Specificity

in retinal

.Nandi

99.3%

Images

Accuracy

using Split

99.4%

And Merge

Algorithm

Fig3: microaneurysns

TABLE II

s.

no

Title

Author

Preproc

essing

Method

Result

1

Automatic Microaneurs ysm Quantificatio n for

Diabetic

Retinopathy screening

A.

Saphar ak, B. Uyyan onvara and S.

Barma n

Green channel/ CLAHE

Feature Extraction/N aïve Bayes classifier

Sensitivity 99.99%

Specificity 83.34%

Accuracy 96.5%

2

Automatic Microaneurs ysm Detection and Characterizat ion through Digital color

Fundus image

C.I.O

Martins

, R.M.S

Vesas, G.L.B

Ramam hi

Green channel/ BG

Subtracti on/MA

Detection segmentation feature extraction classification

Accuracy 84%

3

Detection

and classification of Microaneurs ysm for Diabetic

Retinopathy

J.

Prakas h, K.

Sumath i

CLAHE

Top hat

Transform/M ultiple Gaussian Masks

Not

mentioned

4

Identification and Classificatio n of

Microaneurs ysm for early detection of diabetic

retinopathy

M.

Usman Akram, Shehza d Khalid, Shoab A.

Khan

Green channel. Smoothe ning by morphol ogical opening

Feature extraction/hy brid classifier

Sensitivity 98.64%

Specificity 99.69%

Accuracy 99.40%

5

Automated Detection of Microaneurs ysm using Robust Blob

Descriptors

K.

Adal,

S. Ali, D. Sidiqe

Green channel/ SVD

Hessian operator

Sensitivity 44.64%

6

An algorithm for identification of retinal Microaneurs ysm

A.

Shaeidi

Illuminat ion normaliz ation contrast enhance

ment

Feature extraction classification

-NN

Sensitivity 98.5%

Specificity 96.9%

Accuracy 97.7%

7

Detection of Microanesys ms in Retinal Angiography Image using

the circular Hough

Sekine h Asadi Amiri, Hamid Hassan pour

Red free image

Hough transform/Ci rcular

Accuracy 88.5%

B MICROANEURYSMS

The diabetes key lesion is microanesysms. These are the focal dilatations of retinal capillaries, the diameters of 10 to 100 microns and appear as red dots.

Transform

8

Automatic detection of Diabetic Retinopathy in Non

Dilated RGB Retina;

Fundus Images

Sujith kumar S.b.,

Vipula Singh

Green/G ray scale/Co ntrast

Feature extraction/Cl assification enhancement

Sensitivity 94.44%

Specificity 87.5%

9

Automated

Atsushi

Green

Feature

Rule based

Microaneurs

Mizuta

channel/

extraction/cl

classification

ysm

ni,

double

assificlassifie

170/336,

detection

Chisak

ring

r

ANN

method

o

filter

151/336

based on

Muram

double-ring

atsu

filter in

retinal

fundus

images

10

Identification

A.Alai

Green

Extended

Sensitivity

of diabetic

mahal,

channel/

minima

98.89%

retinopathy

Dr. S.

CE/Medi

transform

Specificity

stages in

Vasuki

an filter

89.70%

human

retinal

images.

11

Automatic

Akara

Green

Extended

Sensitivity

Microanesys

Sophar

channel/

minima

81.61%

ms detection

ak,

Median

transform

Specificity

from Non-

Bunyar

filtering.

99.99%

dilated

it

CLAHE

Accuracy

Diabetic

Uyyan

99.98%

Retinopathy

on vara

Retinal

Images

12

Algorithm

G.

Green

Morphologic

Sensitivity

for detection

Yang,

channel

al

90%

Microaneurs

L.

filtering/Top

ysm in low

Gagno

hat

resolution

n, S.

transform.

color retinal

Wang

Thresholding

images

/Classifier

13

Microaneurs

Lee

Green

Region

Sensitivity

ysm

Streeter

channel/

growing/Feat

56%

Detection in

and

Shade

ure

color fundus

Michae

correctio

extraction

images

l J.

n

classifier

Cree

14

Automatic

R.

Denoisin

Feature

Sensitivity

Identification

Gowth

g/Enhan

extraction,

95.74%.

and

aman

cement

SVM

Sensitivity:

Classificatio

classification

DRIVE

n of

, ELM

SVM is

Microaneurs

(extreme

95.74%

ysm for

learning

ELM is

Detection of

machine)

97.87%.

Diabetic

Diaretdbi,

Retinopathy

SVM is

91.12%

ELM is

94.08%

Specificity:

DRIVE

SVM is

95.89%

ELM is

97.94%.

Diaretdbi, SVM is 95.43%

ELM is 98.34%

15

Internal

Md.

Grayscal

Circular

Sensitivity

Components

Muhid

e/

Hough

88%

Combination

Ahmed

CLAHE

Transform

to Detect

, Dr. K.

Microaneurs

Kumar

ysm

avel

16

Micro

Murug

Green

Extended

Not

aneurysms

an.R,R

chennal

minima

mentioned

detection

eeba

Transform,T

Methods in

Korah

OPHAT,naïv

retinal

e Bayes

Images using

classifier

Mathematica

l

morphology

C HEMORRAGHES

When the wall of a capillary is weakened, it may rupture giving rise to an intra retinal hemorrhages. Usually it is round or oval (dot or blot). Dot hemorrhages appear as bright red dots and are same size as large MAs. Blot hemorrhages are larger lesions they are located within the mid retina and often within or surrounding areas of ischemia.

Fig4: hemorrhages

TABLE III

S.

No

Title

Author

Preproce

ssing

Method

Result

1

Automatic detection of microanuresysm s and the Hemorrhages in digital fundus

Images

Giri Babu Kande,

T. Satya Savithri

Green channel/R ed channel/hi stogram matching

Morphologi cal top hat

/SVM

classifier

Sensitivit y 100%

Specificit y 91%

2

Automatic detection of microanuresysm s and the Hemorrhages in

color eye fundus images

Sergio Bortolin Junior and Danner Welfer

Resizing/ green channel/ contrast enhancem

ent CLAHE

Morpholog y generation

Sensitivit y 87.69%

Specificit y 92.44%

3

Detection of

retinal Hemorrhages

Athira R.V.

Ferlin

Mean

color Backgrou

Splat

feature extraction/

Not mentioned

using splat feature classification

techniques

Deva Shahila D

nd/ gradient operators

watershed segmentatio n KNN

classifier

4

Improvement of automatic hemorrhage detection methods using brightness correction of

fundus images

Yuji Hatanak a, Toshiaki Nakaga wa

RGB to HSV

Bright correction method

Sensitivit y 80%

Specificit y 80%

5

Splat feature classification with application to Retinal Hemorrhage

Detection in Fundus images

L. Tang M. Niemeije r, J.M. Reinhas dt

RGB

Splat feature extraction wrapper approach

Sensitivit y 96%

6

Detection of Hemorrhages

in retinal images

V.

Vijayaku mari

Contrast stretching/

median filtering

Morphologi cal

operation/ cellular NN

Sensitivit y 91.7%

Specificit y 99.9%

7

Classification of hemorrhages pathologies on digital fundus images using a combination of neural network

and tracking algorithms

S.A.

Barman, C.

Sinthana yothin

RGB

image

Multi- perception back propagation

/ matched filter

Efficiency 100%

8

Improvement of Automatic Hemorrhages Detection methods using shapes

recognition

Nidhal Khdhair EI

Abbadi

RGB to Gray

Thresholdin g

Sensitivit y 80.37%

Specificit y 99.53%

9

Automatic detection of Microaneursys m and

Hemorrhage for screening of

retinal diseases

Tareq AI Saeed, Doaa Youssef

Gray level/ frequency domain filtering

Morphologi cal reconstructi on

Not mentioned

10

A survey on usage of Data Mining Techniques in the Detection of Hemorrhages in

Fundus Images

Deepa D,

Sumathi P

Noise removal/c ontrast enhancem ent

Candidate Extraction/ KNN

classifier

Not mentioned

11

The role of Hemorrhages and exudates detection in automated grading of diabetic

retinopathy

Alan D. Fleming, Keith A. Goatman

Not mentioned

D. PERFORMANCE ANALYSIS

120

100

80

p>60

40

20

0

Fig5: Exudate analysis

Snsitivity specificity

Akarasophra

Dr.kekra(mo

Akara Ivosores Nanyang Diptoneel

Alireza Atulkumar Mariagarcia

kittipol Hussain

Sensitivity

specificity

120

100

80

60

40

20

0

Fig6.Microaneurysms Analysis

120

100

80

60

40

20

0

Sensitivity

Specificity

Fig7: hemorrhages

E .CONCLUSION

This Paper will give the idea about the Automatic analysis of Diabetic retinopathy which affects the vision. From this, the new authors can get the understanding about the Automatic Screening and detection of various lesions at the early stage,

and it will give the preventive measures to the blindness. The summary will give the performance analysis of the authors of various Universities also.

REFERENCES

EXUDATES

  1. Akara Sopharak,bunyarit uyyanonvara,Automatic Exudates detection from Diabetic Retinopathy Retinal Image using Fuzzy c means and morphological methods,3rd International conference on Advances in computer science and technology,2007,359-364.

  2. Dr. H. B. Kekre, Dr. Tanuja K. Sarode, Ms. Tarannum Parkar , Hybrid Approach for Detection of Hard Exudates, (IJACSA) International Journal of Advanced Computer Science and Applications, Vol. 4, No. 3, 2013

  3. Anitha Somasundaram, and Janardhana Prabhu,Detection of Exudates for the Diagnosis of Diabetic Retinopathy, International Journal of Innovation and Applied Studies ,Vol. 3 No. 1 May 2013, pp. 116-120.

  4. Mehdi ghafourian fakhar eadgahi, Hamidreza pourreza, Localization of Hard Exudates in Retinal Fundus Image by Mathematical Morphology Operations 2012 2nd International conference on Computer and Knowledge Engineering (ICCKE), October 18-19, 2012, 978-1-4673-4476

  5. M.PonniBala*, S.Mohanapriya, Dr.S Vijayachitra.,Detection of Exudates on Diabetic Retinopathy images Based on Morphological Operation and Connected Component Analysis , International Journal of Advanced Engineering Research and Studies IJAERS/Vol. I/ Issue II/January-March, 2012/86-88.

  6. Akara Sopharak,bunyarit Uyyanonvara,Fine Exudates Detection Using Morphological Reconstruction Enhancement, Journal of Applied Biomedical,volume1,No 1,2010

  7. Ivo Soares,Miguel Castelo Brance,Exudates Dynamic Detection in Retinal Fundus Images based on the Noise Map Ditribution,19th European signal Processing Conference,Spain,2011,page 46-50.

  8. G.Ferdic Mashak Ponnaiah, Capt.Dr.S.Santhosh Baboo, Automatic optic disc detection and removal of false exudates for improving Retinopathy Classification Accuracy, International Journal of Scientific and Research Publications, Volume 3, Issue 3, March 2013

  9. Nan Yang, Hu Chuan Lu ,An Effective Framework for Automatic Segmentation of Hard Exudates in Fundus images, Journal of circuits, Systems and Computers Vol 2,No 1,2013

  10. Diptoneel Kayal, Sreeparna Banerjee,Detection of hard exudates using Simulated Annealing Based Thresholding mechanism in Digital Fundus Image, Journal of computer science and Information Technology, CSCP-2013,pp 119-124.

  11. Sidra Rashid and Shagufta,Computerised Exudate Detection in Fundus Images Using Statistical Feature Based Fuzzy C mean Clustering, International journal of Computing and Digital System No 3,135-145,2013

  12. Alireza Osareh,majid Mirmehdi,Comparative Exudate Classification using Support Vector Machines and Neural Networks, Journal of Medical Image Computing,springer-verlag 2002,pp413-420

  13. Atul Kumar,Manish Srivastava,A.K sinha,A Segment Based Technique for Detecting Exudate From Retinal Fundus Image, International Journal of Computer science and engineering Technology,vol 3, No 7,2012

  14. Maria Garcia,clara I.Sanchez,Neural network Based detection of Hard Exudates in Retinal Images, An international journal of computing

    Methodology and Software systems in Biomedical Practice,ELSEVIER,2009,vol 93,page 9-19.

  15. Kittipol Wisaing ,Nualsawat ,Automatic Detection of Exudates in diabetic retinopathy images, Journal of Computer Science 8980,1304- 1313,2012

  16. Hussain F.Jaafer,Asoke K.Nandi ,Automated Detection Of Exudates in Retinal Images Using a Spilt And- Merge Algorithm,18th European Signal Processing conference 2010,page 1622-1626.

MICROANEURYSM

  1. A.Sopharak, B.Uyyanonvara and S.baraman,Automatic micro aneurysm Quantification for Diabetic Retinopathy Screening, world Academy of Science, engineering and Technology 2013,page 1735- 1738

  2. C.I.O.Martins ,R.M.S.veras,G.L.B.Ramalho,Automatic Microaneursysm Detection and Characterization through Digital Color Fundus images, International Joint Conference-Brazilian Symposium on Artificial Intelligence and Brazilian symposium on Neural Networks,2010

  3. J.praKash, K.Sumathi,detection and Classification of Microaneursysm for Diabetic retinopathy, International journal of Engineering research and Applications, 2013,page 31-36

  4. M.usman Akram, Shehzad Khalid, Shoab A.Khan,Identification and classification of micro aneurysms for Early detection of diabetic retinopathy, Pattern Recognition,ELSEVIER,2012

  5. K. Adal, S. Ali, D. Sidib, Automated Detection of Micro aneurysms Using Robust Blob Descriptors, SPIE Medical Imaging – Computer- Aided Diagnosis, Orlando – FL : United States (2013).

  6. A.Shaeidi,An Algorithm for Identification of Retinal Micrianeurysms,Journal of Serbian society for Computational Mechanics ,vol 4,No1,2010,pp 43-51

  7. Sekineh Asadi Amiri, Hamid Hassan pour, Detection of Micro aneurysms in Retinal Angiography Image using the circular Hough Transform, Journal of Advances in computer Research ,vol 3,No 1,2012,pages 1-12

  8. Sujith Kumar S.B, Vipula Singh ,Automatic Detection of Diabetic Retinopathy in Dilated RGB Retinal Fundus Images, international journal of computer Applications ,volume 47,No.9,2012

  9. Atsushi Mizutani, Chisako Muramatsu,Automated Microaneursysm Detection Method based on Double Ring Filter in Retinal Fundus Images, medical Imaging 2009 proceedings of SPIE vol 7260,IN-1

  10. A.Alaimahal,Dr.S.Vasuki,Identification of Diabetic Retinopathy Stages in Human Retinal Images, International journal of Advanced Research on Computer Engineering and Technology ,Volume 2, issue 2,2013

  11. Akara Sopharak, Bunyarit uyyanonvara,Automatic Microaneursysm Detection From Non Dilated Diabetic retinopathy retinal Images, proceedings of the world congress on engineering 2011,vol II ,page 6-8

  12. G.Yang, L.Gagnon, S.Wang,Algorithm For Detecting Micro aneurysms in Low Resolution Color Retinal images,2001

  13. Lee Streeter and Michael J.Cree,Microaneurysm Detection in Color Fundus Images, image and Vision Computing NZ, 2003,page 280-283

  14. R.Gowtham,Automatic Identification and Classification of Micro aneurysms for Detection of Diabetic Retinopathy, International journal of Research in Engineering and technology, 2014,vol 03,issue 02

  15. Md.Muhid Ahmed, Dr.K.Kumaravel,Internal Components Combination to Detect Microaneurysm, IJAIR,2013,vol 2,issue 5, page 155-158

  16. Murugan.R, Dr. Reeba Koreh, Microaneurysms Detection Methods in Retinal Images Mathematical Morphology , International journal of Advances in Engineering science and technology, 2003

HEMORRHAGES

  1. Giri Babu Kande, T. Satya Savithri et al, Automatic detection of microanuresysms and the Hemorrhages in digital fundus Images, Journal of Digital Imaging 2010, 23(4), 430 437.

  2. Sergio Bortolin Junior and Danner Welfer, Automatic detection of microanuresysms and the Hemorrhages in color eye fundus images, International Journal of Computer Science and Information Technology,Vol 5, No 5, 2013.

  3. Athira R.V. Ferlin Deva Shahila D, Detection of retinal Hemorrhages using splat feature classification techniques, Journal of Engineering Research and Applications, Vol 4, Issue 1 (version 3), 2014, pp. 327 330.

  4. Yuji Hatanaka, Toshiaki Nakagawa, Improvement of automatic hemorrhage detection methods using brightness correction of fundus images, Journal of Medical Imaging, 2088, Vol 6915.

  5. L. Tang M. Niemeijer, J.M. Reinhasdt et al, Splat feature classification with application to Retinal Hemorrhage Detection in Fundus images, IEEE Transactions, Medical imaging, 2012.

  6. V. Vijayakumari, Detection of Hemorrhages in retinal images, Indian Journal of Applied Research, Vol 3, Issue 7, 2013.

  7. S.A. Barman, C. Sinthanayothin, Classification of Hemorrhages pathologies on digital fundus images using a combination of neural network and tracking algorithms.

  8. Nidhal Khdhair EI Abbadi et al, Improvement of Automatic Hemorrhages Detection methods using shapes recognition, Journal of Computing and Applications.

  9. Tareq AI Saeed, Doaa Youssef et al, Automatic detection of Microaneursysm and Hemorrhage for screening of retinal diseases, 3rd International Conference on Intelligent Computational systems, 2013, 39 43.

  10. Deepa D, Sumathi P, A survey on usage of Data Mining Techniques in the Detection of Hemorrhages in Fundus Images, International Journal of Advanced Research in Computer Science and Software Engineering, Vol 3, Issue 10, 2013.

  11. Alan D. Fleming, Keith A. Goatman et al, The role of Hemorrhages and exudates detection in automated grading of diabetic retinopathy, Br. Journal of Opthalmol, 2012,706 711.

BIOGRAPHIES

E.Dhiravida selvi, received B.E in Electronics and Communication Engineering from The Indian engineering college, Manonmani Sundaranar University, tirunelvelli, Tamilnadu, India,in the year1996, Post graduate degree in M.E

Communication system from Thiyagarajar College of engineering Madurai, Tamilnadu, India in the year of 1998 and Pursing Ph.D at SathyaBama University with a specialization in Medical Image Processing. She started her academic carrier in the year 1999 as Lecturer. Currently, she is working as a Hod in the Mohamed Sathak A.J college of engineering ,Chennai,tamilnadu,India. He is the life member of IETE,ISTE, New Delhi, India.

V.Rajamani, received B.E in Electronics and Communication Engineering from national Engineering College,Madurai Post graduate degree in M.E. Applied Electronics from Govt. College of Technology, degree from the Institute of Technology, Banaras

Hindu University, Varanasi, Uttar Pradesh, India in 1999 with a specialization in semiconductor device modeling for optical communication receivers.. Currently, he is working as a Principal in the IndraGanesan College of Engineering, Tiruchirappalli, Tamilnadu, India. He has published more than 130 papers in the referred national and international journals and conference proceedings. Under his guidance, 10 research scholars have completed their doctoral degrees. He has also completed 10 PG dissertations also. His area of interest includes Device Modeling, VLSI Design, Image Processing and Optical Networking and Communication. He is the life member of ISTE, New Delhi, India and member in IAENG.

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